Correlative Light and Electron Microscopy (CLEM)
Combines fluorescence light microscopy and electron microscopy (EM) imaging of the same sample.
Electron Microscopy (EM)
Delivers structural information and also the context in which the target structures
are embedded at very high resolution. But EM provides very limited information in terms of living biological processes and functions.
Fluorescence Light Microscopy (FLM)
On the other hand is a very sensitive method to observe and analyze biological processses and functions inside fixed and living biological samples. In addition, FLM allows rapid screening of large areas and fast determination of regions of interest (ROI) which can be quickly recognized in the electron microscope.
Is the sample preparation method to maintain samples in the most life-like state as possible.
Connects the benefits of all these techniques. It combines the individual advantages from cryo fixation, FLM and EM by time-effective imaging of identical, artefact-free samples and overlaying the complementary information to win greater understanding.
Trust in reliability
Safely transfer your cryo samples and load them into the cryo stage - the cryo transfer shuttle keeps your samples frost free to yield high quality light microscopy images.
Find what you are looking for
We developed the world`s first cryo objective, so that you can easily and quickly localize target structures. The low working distance for high resolution creates beautiful high image quality - see for yourself!
You will find loading and unloading of samples very quick with the sample transfer and loading system. Additionally, you need less time for cryo EM operation and analysis, as samples are in excellent condition and target structures accurately located.
Making your work life easier is a top priority during the development of our solutions. This is why a sensor controls the stage temperature and why our sample transfer and loading system is so intuitive.